[Bio3] Nov 10/11 Pair SW for Electron and Truth

  1. Please work on the pair SW mindfully.
  2. Make sure you understand each answer you write on your 1 whole sheet of paper.
  3. Submit your worksheets next week.

Overview: Enzymes and activation energy

View Part I of the animation at http://www.sumanasinc.com/webcontent/animations/content/enzymes/enzymes.html , click on “show narrative” and answer the questions that follow.

  • What is the activation energy (EA) of a reaction?
  • How do enzymes affect the EA of a reaction?

Enzyme structure and function
View http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter2/animation__how_enzymes_work.html, click on “text” and answer the next question:

  • On a molecular level, how does the shape of an enzyme enable it to perform its function? Use all the following terms in your answer: active site, substrate, enzyme-substrate complex, and product.

View http://www.wiley.com/college/boyer/0470003790/animations/enzyme_binding/enzyme_binding.htm, click on “Binding Models” and answer the next question:

  • What is the difference between Emil Fisher’s lock-and-key model and Daniel Koshland’s induced fit model? What is the current model like?

Factors that affect enzyme action

  • Knowing what you know about the nature of enzymes, predict how the following factors affect enzyme function:

Factors Effect on reaction rate if factor is reduced/decreased Effect on reaction rate if factor is raised/increased Brief explanation as to why these factors affect enzyme function and reaction rates in that way

    • a. Enzyme concentration
    • b. Substrate concentration
    • c. Inhibitor concentration
    • d. Temperature
    • e. Size of container
    • f. pH
  • View http://moleculesoflife2010.wikispaces.com/file/view/Enzyme+Model.swf and test your hypotheses using controlled experiments (you may need to use a timer to assess reaction rates). Do your results agree with your predictions? Write a short summary of your results below.

View http://programs.northlandcollege.edu/biology/Biology1111/animations/enzyme.html and click on “Enzyme Inhibitors” and answer the question below.

  • What is the difference between a competitive and noncompetitive inhibitor?

View http://programs.northlandcollege.edu/biology/Biology1111/animations/enzyme.html and click on “Allosteric Enzymes” and answer the question below.

  • What are allosteric enzymes?
  • We learned in Bio2 that the haemoglobin molecule exhibits cooperativity. What happens to the structure of haemoglobin once oxygen binds to a subunit?

View http://programs.northlandcollege.edu/biology/Biology1111/animations/enzyme.html and click on “Feedback Inhibition” and answer the question below.

  • Feedback inhibition regulates metabolic pathways that use more than one enzyme. How does feedback inhibition work?

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